Risk genes associated with paediatric-onset MS but not with monophasic acquired CNS demyelination

Fifty seven genetic loci have been identified in adult patients with MS in a genome-wide association study (GWAS). This study investigated if these loci are associated with a risk of paediatric-onset MS and if they can be helpful in predicting MS diagnosis in children presenting with acquired demyelinating syndromes (ADS).

The study included 188 children with ADS and 53 of these were diagnosed with MS, as well as 466 patients with adult-onset MS and 2,046 adult controls. The genetic effect was calculated using weighted genetic risk scores (wGRS).

The results showed that the mean wGRS was significantly higher for patients with paediatric-onset MS compared to patients with an ADS and controls. There was no difference between subjects with ADS and controls. By including sex and HLA-DRB1*15 to the 57 genetic loci, it improved the ability to discriminate between children with MS and ADS. Therefore the 57 single nucleotide polymorphisms associated with adult-onset MS also confers an increased risk to paediatric-onset MS but not to a once off ADS.

Authors: van Pelt ED, Mescheriakova JY

Source: Neurology. 2013 Nov 6. [Epub ahead of print]

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