The aim of this study was to compare regional grey matter (GM) volume changes in people with relapsing-remitting MS with progressive and stable disability, using voxel-based morphometry (VBM).
Baseline and one year follow-up 3D T1-weighted MRI scans were acquired from people with relapsing-remitting MS. Patients were matched pair-wise in relation to age, gender, disease duration, medication, and baseline EDSS, with either (a) progressive EDSS or stable EDSS, and (b) patients with progressive versus stable Multiple Sclerosis Functional Composite (MSFC). Using VBM, they analysed longitudinal regional differences in GM volumes in the progressive and stable EDSS and MSFC groups.
Results from this study suggested that cortical regional GMV reductions in the right precuneus and in the right postcentral gyrus were associated with disability progression, as measured by the EDSS. Further longitudinal GM volume reductions occurred in the right orbicular gyrus, in the progressive MSFC group, but no between group differences were seen. Overall, these results suggest a direct association of disability progression and regional GM atrophy in relapsing-remitting MS.
Authors: Hofstetter L, Naegelin Y
Source: Mult Scler. 2013 Jun 26. [Epub ahead of print]
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