Postpartum relapses increase the risk of disability progression in MS: the role of disease modifying drug

This prospective study followed up 350 pregnancies over a six-year period in females with MS and assessed the risk of relapse, disability progression and the role of disease modifying drugs (DMDs) in the year after delivery. 42.3% of patients had at least one relapse in the 12 months following delivery. An EDSS of ≥2.0 at the time of conception and a higher number of relapses before and during pregnancy were related to a higher risk of postpartum relapses. The resumption of DMD post-delivery marginally reduced the risk of post-partum relapses.

Therefore, there is an increased risk of postpartum relapses and disability accumulation in females with higher disease activity before and during pregnancy.

Authors:Portaccio E, Ghezzi A
Source: J Neurol Neurosurg Psychiatry. 2014 Jan 8. doi: 10.1136/jnnp-2013-306054. [Epub ahead of print]
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