Patterns and predictors of naturally occurring change in depressive symptoms over a 30-month period in multiple sclerosis

This study looked at the changes in depressive symptoms in 269 people with RRMS over a 30-month period as well as the demographic, clinical and behavioural predictors of these changes. The subjects involved in the study completed the Hospital Anxiety and Depression Scale (HADS), a demographic/clinical scale, Godin Leisure-Time Exercise Questionnaire (GLTEQ) and Patient Determined Disease Steps (PDDS) every six months over the 30-month period.

Data analysis demonstrated a two class model for changes in HADS. Class one was those with fewer depressive symptoms and decrease in depressive symptoms over time, while class two had more depressive symptoms and worsening of the HADS scores. Those that were older, married, employed and physically active had a greater likelihood of belonging to C1 than C2. This study demonstrates that depressive symptoms change over time, which can be predicted by both modifiable and non-modifiable factors as outlined above.

Authors: Ensari I, Motl RW
Source: Mult Scler. 2013 Sep 25. [Epub ahead of print]

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