Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS

Neurobiology and immunology:

This exploratory study looked at naïve CD4 T-cell biology in patients with secondary progressive MS (SPMS), to determine if altered naïve CD4 T-cell gene expression contributed to the development of disease progression.

The study included 19 SPMS patients and 14 healthy controls and the gene expression profiles of naïve CD4 T cells were compared between the groups.
They found that opposing naïve CD4 T-cell gene expression patterns segregated SPMS patients into two groups: SP-1, which had a short RRMS duration and SP-2, which had a long RRMS duration.

The SP-1 group up-regulated a number of immune genes, including genes within T-cell receptor (TCR) and toll-like receptor (TLR) signalling pathways, compared to controls and SP-2 patients, while the SP-2 group down-regulated a number of immune genes in comparison to healthy controls.
Therefore, differences in naïve CD4 T-cell biology identified patients with MS having different rates of development of secondary progression.

Authors: Zastepa E, Fitz-Gerald L
Source: Neurology. 2014 Jan 22. [Epub ahead of print]
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