Multiple sclerosis: identification of temporal changes in brain lesions with computer-assisted detection software

This study from the US looked at the performance of a locally developed computer-assisted detection (CAD) software, which they used to track temporal changes in MS brain lesions. CAD tracks T2-bright MS lesions between two time points in a 3D high-resolution isotropic FLAIR MR sequence on 3T. This computer based programme is made up of an image-processing pipeline and displays scrollable difference maps used as an aid to the neuroradiologist for assessing lesional change. 

The researchers looked at 98 randomly chosen, paired MR examinations from 88 patients with definite MS and compared the diagnostic accuracy and duration of the interpretation of the CAD-assisted and routine clinical interpretations. They found that CAD interpretation showed higher sensitivity than a clinical report (87% vs 77% respectively). Lesion-wise analysis demonstrated improved sensitivity of CAD over a routine clinical interpretation of 40-48%. The mean interpretation time for the software assisted programme was 2.7min. Overall, this study demonstrates the potential of including CAD software in neuroradiology practice for the detection of MS lesional change, as well as the potential benefit in clinical trials.

Authors: Bilello M, Arkuszewski M
Source: Neuroradiol J. 2013 May 10;26(2):143-50. Epub 2013 May 10

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