This prospective study compared conventional and non-conventional MRI characteristics of patients with familial and sporadic MS. 758 patients were enrolled, with 25.9% who had a positive family history of MS.
Patients were assessed using measurements of lesions, brain atrophy, magnetization transfer ratio (MTR) and diffusion weighted imaging. Results from this study showed that familial MS was associated with more severe T1-lesion volume and a trend for lower MTR of T1-lesion volume than the sporadic MS group. There was no clinical difference between familial and sporadic MS patients. Therefore, a better understanding of the genetic and/or epigenetic influences causing these differences can help in identifying MS patients at risk for more aggressive disease.
Authors: Tipirneni A, Weinstock-Guttman B,
Source: Mult Scler. 2012 Dec 11. [Epub ahead of print]
Read the abstract