In this study from Italy, they present the results from the 6-year
extension of the previous 1-year prospective longitudinal study on the
evolution of cortical pathology in a group of MS patients with
relatively mild disease (>15 years duration and EDSS <3), compared
with a group of relapsing-remitting MS patients. Results detected 70.5%
cortical lesions in early RRMS and 53.3% in benign MS at baseline.
After 6 years, new cortical lesions were observed in 84.2% of the early
RRMS and in 55.5% of the benign MS patients. In addition to this,
cortical thinning had increased significantly in several cortices in
RRMS, however, in those with benign MS, only in the occipital-temporal
and superior parietal gyrus.
Overall, this study shows
significant cortical sparing in MS patients who have the most favourable
clinical course. Patients with classical RRMS accumulate both focal and
diffuse cortical damage, which may explain why the majority of these
patients progress to the secondary progressive phase. This raises the
question of evaluating grey matter damage in addition to white matter
damage, in order to increase the accuracy in identifying any possible
favourable courses in MS.
authors: Calabrese M, Favaretto A, Poretto V
source: Mult Scler. 2012 Oct 15. [Epub ahead of print]
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