Evaluation of inner retinal layers in patients with MS or neuromyelitis optica using optical coherence tomography

This cross-sectional study from Brazil looked at the inner retinal layers in the macula using frequency domain optical coherence tomography (fd-OCT), in five different groups-controls, neuromyelitis optica (NMO), longitudinally extensive transverse myelitis (LETM), MS with a history of optic neuritis (MS-ON) and MS without a history of optic neuritis (MS non-ON).

From each of the OCT scans, they calculated the thickness of the retinal nerve fiber layer (RNFL), the combined retinal ganglion cell and inner plexiform layers (RGCL+) and the inner nuclear layer (INL). Results from this study showed that the NFL was significantly thinner than in controls for all patient groups. The INL thickness was significantly thicker than in controls for the patients with NMO and LETM, but not for those with MS-ON or MS non-ON. INL thickening occurs in patients with NMO and LETM, therefore this may be useful for differentiating between NMO and MS.

Authors: Fernandes DB, Raza AS, Nogueira RG

Ophthalmology. 2012 Oct 17. [Epub ahead of print]

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