Detecting cognitive dysfunction in a busy multiple sclerosis clinical setting: a computer generated approach

This study looked at a brief (20 minutes, computerized battery of tests to detect cognitive differences between 42 subjects with clinically isolated syndrome, 44 subjects with RRMS, 14 with PPMS and 37 with SPMS.

The cognitive tests included 5 tests-the Stroop colour test, the SDMT, the Paced Visual Serial Addition Test (PVSAT) 4s and 2s trials and a speed of cognitive index tested by subtracting simple reaction time from choice reaction time.

They found significant group differences in all cognitive tests apart from PVSAT 2s trial. SPMS patients were most impaired on the cognitive tests, CIS subjects were least impaired, while RRMS and PPMS were similarly affected. Therefore these computerized battery of tests being relatively quick to administer and easy to administer, have a potential role for use in a busy clinic setting.

Authors: Lapshin H, Audet B
Source: Eur J Neurol. 2013 Nov 7. doi: 10.1111/ene.12292. [Epub ahead of print]

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