Axial 3D gradient-echo imaging for improved MS lesion detection in the cervical spinal cord at 3T

This study from the US, looked at axial 3D gradient-recalled echo (GRE) sequences performed both with and without a magnetization transfer prepulse and compared them to T2-weighted fast-spin-echo (T2-FSE) images, for the detection of MS lesions in the cervical cord on 3T.

The T2-FSE is the clinical standard acquisition for lesion detection in MS. They studied 62 people with MS and 19 healthy volunteers. Results from this study showed that the number and volume of lesions detected was more than three times as high on both GRE sequences compared to T2-FSE, therefore demonstrating that axial 3D GRE sequences, with or without an MT-prepulse, improves MS lesion detection.

Scan quality was similar across sequences with about 5% of GRE sequences affected by artefact. The acquisition time was very similar for both sequences. Here we see enhanced lesion detection in the spinal cord on MR images which may help improve diagnostic accuracy.

Ozturk A, Aygun N, Smith SA

Neuroradiology. 2012 Dec 4. [Epub ahead of print]

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