Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy

Diagnosis, monitoring and biomarkers:

This interesting prospective study looked at whether serum apolipoproteins (Apo) levels were associated with disease progression in clinically isolated syndrome (CIS). The study included 181 CIS patients and serum levels of ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) were measured prior to commencing treatment with intramuscular interferon-β. Clinical and MRI measures were obtained at baseline, as well as at six months, 12 months and 24 months after commencing therapy.

Results demonstrated that higher levels of ApoB were associated with an increased number of new T2 lesions and an increased number of new or enlarging T2 lesions over two years. There was a 16% increase in the number of new T2 lesions for every 10mg/dl increase of baseline ApoB over two years. There was no association between ApoI, ApoII, ApoE and Lpa and T2 lesions. Higher ApoE levels were associated with greater deep grey matter atrophy. A 1mg/dl increase in ApoE levels was associated with a  one % increase in deep grey matter atrophy over two years.

Authors: Browne RW, Weinstock-Guttman B
J Neurol Neurosurg Psychiatry. 2014 Jan 27. doi: 10.1136/jnnp-2013-307106. [Epub ahead of print]
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